Endocrine Abstracts

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...

Introduction: The pathogenesis of idiopathic hirsutism (IH) is not clear. On the other hand, human skin possesses all the enzymes necessary for androgen synthesis and catabolism indicating that it is an independent peripheral endocrine organ. Thus, in the present study we aimed to investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumblical skin and the arm of wo...

Purpose: This study aims to compare serum urocortin-3 levels in women with PCOS and healthy women, and establish what role urocortin-3 levels play in PCOS.Methods: Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and BMI. Fasting blood glucose (FBG), insulin, hs-CRP, urocortin-3, and free testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance.<p clas...

Aim: Bisphenol A (BPA) is the most common endocrine disruptor among environmental estrogens. BPA is an ingredient that is commonly used in polycarbonate plastics. In this study, our main concern is to measure the levels of BPA in premenopausal obese women and to examine the relationship of BPA with adiponectin and leptin.Materials and methods: 47 obese women and 39 non-obese healthy women were enrolled in this study. All participants were premenopausal. ...

Introduction: Several studies have shown that prediabetic patients had increased concentrations of inflammatory markers and this association is independent of underlying obesity. Netrophil to lymphocyte ratio (NLR) is considered as a new inflammatory marker and has been studied extensively in a variety of clinical conditions especially in solid tumours and cardiovascular diseases. Studies evaluating the subclinical inflammation in prediabetes revealed positive association of s...

Aim: Disabilities of the arm, shoulder, and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH questionnaire in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and 10...

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and 107 men) who had T2DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign, and tendinitis was assessed. Diabetic retinopathy was assessed by direct ophthalmoscopy. Urinary albumin excretion was de...

Aim: Diabetes mellitus is a chronic metabolic condition characterised by persistent hyperglycaemia with resultant morbidity and mortality related primarily to its associated microvascular and macrovascular complications In this study our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and...

Aim: The intima–media thickness (IMT) measurement of the common carotid artery is recognised as an important marker of systemic atherosclerosis. It may be useful in predicting the cardiovascular events, since it is related to the severity of coronary artery disease. The aims of this study were to analyse whether correlations exist between the IMT of the common carotid artery and the main clinical and biochemical parameters in patients with primary hyperparathyroidism (PHP...

Aim: To evaluate serum and intranodular vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) level thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (62 women and 18 men) with thyroid nodules were included in this prospective study. Thyroid function tests, fine needle aspiration biopsies, ultrasonographic and scintigraphic evaluation were r...